Damage to Circulatory and Nervous Systems Patients with diabetes -- whether type 1 or 2 -- have an increased risk of severe complications if the disease goes undiagnosed and untreated, or if it is poorly managed. The high blood glucose levels that occur in diabetes make it easier for blockages to form in the body's arteries. High blood glucose can also damage nerves in the body, causing numbness and tingling, especially in the legs and feet.

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